TNNI2 Primary Antibody

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Description

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

Product Overview
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
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Western Blot
Figure 1: Western blot analysis using TNNI2 mAb against human TNNI2 (AA: 1-182) recombinant protein.(Expected MW is 46.8 kDa)
Figure 1: Western blot analysis using TNNI2 mAb against human TNNI2 (AA: 1-182) recombinant protein.(Expected MW is 46.8 kDa)
Western Blot
Figure 2: Western blot analysis using TNNI2 mAb against HEK293 (1) and TNNI2(AA: 1-182)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using TNNI2 mAb against HEK293 (1) and TNNI2(AA: 1-182)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded cardiac muscle tissues using TNNI2 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded cardiac muscle tissues using TNNI2 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 4: Immunohistochemical analysis of paraffin-embedded striated muscle tissues using TNNI2 mouse mAb with DAB staining.
Figure 4: Immunohistochemical analysis of paraffin-embedded striated muscle tissues using TNNI2 mouse mAb with DAB staining.
Flow cytometric
Figure 5: Flow cytometric analysis of NIH/3T3 cells using TNNI2 mouse mAb (blue) and negative control (red).
Figure 5: Flow cytometric analysis of NIH/3T3 cells using TNNI2 mouse mAb (blue) and negative control (red).
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
For Research Use Only. Not for use in diagnostic procedures.

Catalog#: 30278

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