TNK1 Primary Antibody
Item Information
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Price
Description
TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Product Overview
Entrez GenelD
8711
Aliases
MGC46193; TNK1
Clone#
1B5G3
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Oncogene. 1996 Feb 15;12(4):903-13.
2. Oncogene. 2003 Jun 5;22(23):3562-77.
3. Oncogene. 2007 Oct 4;26(45):6536-45.
2. Oncogene. 2003 Jun 5;22(23):3562-77.
3. Oncogene. 2007 Oct 4;26(45):6536-45.
Product Image
Western Blot
Figure 1: Western blot analysis using TNK1 mouse mAb against truncated TNK1-His recombinant protein (1).
For Research Use Only. Not for use in diagnostic procedures.