TNFRSF1A

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesFPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55
Clone#2G11C9
Entrez GenelD7132
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeMouse IgG1
ImmunogenPurified recombinant fragment of human TNFRSF1A (AA: extra 30-211) expressed in E. Coli.
MW51KDa
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
extra(30-211)
Catalog#: 32298
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Images
Elisa
Figure 1 :Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1 :Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using TNFRSF1A mAb against human TNFRSF1A (AA: extra30-211) recombinant protein. (Expected MW is 23.4 kDa)
Figure 2:Western blot analysis using TNFRSF1A mAb against human TNFRSF1A (AA: extra30-211) recombinant protein. (Expected MW is 23.4 kDa)
Western Blot
Figure 3:Western blot analysis using TNFRSF1A mAb against HEK293-6e (1) and TNFRSF1A (AA: extra 30-211)-hIgGFc transfected HEK293-6e (2) cell lysate.
Figure 3:Western blot analysis using TNFRSF1A mAb against HEK293-6e (1) and TNFRSF1A (AA: extra 30-211)-hIgGFc transfected HEK293-6e (2) cell lysate.
Immunohistochemical analysis
Figure 4:Immunofluorescence analysis of Hela cells using TNFRSF1A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Figure 4:Immunofluorescence analysis of Hela cells using TNFRSF1A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Immunofluorescence analysis
Figure 5:Flow cytometric analysis of THP-1 cells using TNFRSF1A mouse mAb (green) and negative control (red).
Figure 5:Flow cytometric analysis of THP-1 cells using TNFRSF1A mouse mAb (green) and negative control (red).
Immunofluorescence analysis
Figure 6:Flow cytometric analysis of Jurkat cells using TNFRSF1A mouse mAb (green) and negative control (red).
Figure 6:Flow cytometric analysis of Jurkat cells using TNFRSF1A mouse mAb (green) and negative control (red).
Product Overview
Description

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.

References (references)
References (references)1,Biomed Res Int . 2020 Sep 24;2020:2451854.
2,Oral Surg Oral Med Oral Pathol Oral Radiol . 2020 Sep;130(3):283-291.e2.