TNFRSF11B Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesOPG; TR1; OCIF; MGC29565; TNFRSF11B
ProductOrderT
Clone#5G2
Entrez GenelD4982
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human TNFRSF11B expressed in E. Coli.
MW60kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
22-401
Catalog#: 30125
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Images
Western Blot
Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B(AA: 22-401)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B(AA: 22-401)-hIgGFc transfected HEK293 (2) cell lysate.
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of HL-60 cells using TNFRSF11B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 2: Immunofluorescence analysis of HL-60 cells using TNFRSF11B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric
Figure 3: Flow cytometric analysis of HL-60 cells using TNFRSF11B mouse mAb (green) and negative control (purple).
Figure 3: Flow cytometric analysis of HL-60 cells using TNFRSF11B mouse mAb (green) and negative control (purple).
Product Overview
Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

References (references)
References (references)1. Am J Hypertens. 2009 Nov;22(11):1167-70.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.