TNFRSF11B Primary Antibody
Item Information
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Size
Price
Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Product Overview
Entrez GenelD
4982
Aliases
OPG; TR1; OCIF; MGC29565; TNFRSF11B
Clone#
5G2
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human TNFRSF11B expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ICC (Immunocytochemistry)
1/200 - 1/1000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1. Am J Hypertens. 2009 Nov;22(11):1167-70.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.
Product Image
Western Blot
Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B(AA: 22-401)-hIgGFc transfected HEK293 (2) cell lysate.
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of HL-60 cells using TNFRSF11B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric
Figure 3: Flow cytometric analysis of HL-60 cells using TNFRSF11B mouse mAb (green) and negative control (purple).
For Research Use Only. Not for use in diagnostic procedures.