TNFRSF11A

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesFEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R
Clone#2B5A2
Entrez GenelD8792
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeMouse IgG1
ImmunogenPurified recombinant fragment of human TNFRSF11A (AA: extra 30-212) expressed in E. Coli.
MW66kDa
Species ReactivityHuman, Mouse, Rat
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
extra(30-212)
Catalog#: 32312
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Images
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using TNFRSF11A mAb against human TNFRSF11A (AA: extra 30-212) recombinant protein. (Expected MW is 46 kDa)
Figure 2:Western blot analysis using TNFRSF11A mAb against human TNFRSF11A (AA: extra 30-212) recombinant protein. (Expected MW is 46 kDa)
Western Blot
Figure 3:Western blot analysis using TNFRSF11A mAb against HEK293-6e (1) and TNFRSF11A (AA: extra 30-212)-hIgGFc transfected HEK293-6e (2) cell lysate.
Figure 3:Western blot analysis using TNFRSF11A mAb against HEK293-6e (1) and TNFRSF11A (AA: extra 30-212)-hIgGFc transfected HEK293-6e (2) cell lysate.
Western Blot
Figure 4:Western blot analysis using TNFRSF11A mouse mAb against Rat brain (1), Mouse kindey (2), and Rat kindey (3) cell lysate.
Figure 4:Western blot analysis using TNFRSF11A mouse mAb against Rat brain (1), Mouse kindey (2), and Rat kindey (3) cell lysate.
Product Overview
Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

References (references)
References (references)1.Orthod Craniofac Res. 2020 May;23(2):210-222.
2.J Bone Miner Res. 2019 Oct;34(10):1873-1879.