TAB2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCHTD2; FLJ21885; KIAA0733; MAP3K7IP2; TAB2
ProductOrderT
Clone#3B5
Entrez GenelD23118
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human TAB2 expressed in E. Coli.
MW80kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
1-300
Catalog#: 30123
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Images
Western Blot
Figure 1: Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2(AA: 1-300)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2(AA: 1-300)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 2: Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and negative control (purple).
Figure 2: Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and negative control (purple).
Product Overview
Description

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

References (references)
References (references)1. J Clin Endocrinol Metab. 2006 Mar;91(3):1056-61.
2. Sci STKE. 2006 Oct 17;2006(357):re13.
3. Am J Hum Genet. 2010 Jun 11;86(6):839-49.