SYP Primary Antibody

Item Information
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Description

Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.

Product Overview
Entrez GenelD
6855
Aliases
MRXSYP; SYP
Clone#
7H12
Host / Isotype
Mouse / IgG1
Species Reactivity
Human, Rat
Immunogen
Purified recombinant fragment of SYP expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Cancer. 2007 Oct 15;110(8):1776-81.
2. J Gastroenterol Hepatol. 2008 Oct;23(10):1574-85.
3. Virchows Arch. 2009 Aug;455(2):125-32.
Product Image
Western Blot
Figure 1: Western blot analysis using SYP mouse mAb against rat brain tissue lysate.
Figure 1: Western blot analysis using SYP mouse mAb against rat brain tissue lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Small Intestine, myenteric plexus tissues using anti-SYP mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Small Intestine, myenteric plexus tissues using anti-SYP mouse mAb
For Research Use Only. Not for use in diagnostic procedures.