SYK Primary Antibody

Item Information
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Description

SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

Product Overview
Entrez GenelD
6580
Aliases
FLJ25043; FLJ37489; DKFZp313N1010
Clone#
8C1A3
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Blood. 2006 Nov 15;108(10):3352-9
2. Int J Mol Med. 2006 Oct;18(4):547-57.
3. J Exp Med. 2006 Dec 25;203(13):2829-40.
Product Image
Western Blot
Figure 1: Western blot analysis using SYK mouse mAb against truncated SYK-His recombinant protein (1) and PMA induced THP-1 cell lysate (2).
Figure 1: Western blot analysis using SYK mouse mAb against truncated SYK-His recombinant protein (1) and PMA induced THP-1 cell lysate (2).
For Research Use Only. Not for use in diagnostic procedures.