Stat5 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesMGF; STAT5A
ProductOrderS
Clone#7F7A4
Entrez GenelD6776
FormulationPurified antibody in PBS with 0.05% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenSynthesized peptide of human Stat5 (AA: KAVDG[pTyr]VKPQIK).
MW90.6kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
Sequence
KAVDG[pTyr]VKPQIK
Catalog#: 30723
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Images
Flow cytometric
Figure 1: Flow cytometric analysis of Hela cells using Stat5 mouse mAb (green) and negative control (red).
Figure 1: Flow cytometric analysis of Hela cells using Stat5 mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

References (references)
References (references)1. Anticancer Res. 2012 Jul;32(7):2885-93.
2. Leuk Lymphoma. 2010 Oct;51(10):1895-901.