ST13 Primary Antibody

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Description

ST13 (suppression of tumorigenicity protein 13), also known as Hip (HSP70-interacting protein), is one of several co-chaperones that regulate activities of the HSP70 chaperone family. The homo-oligomeric protein Hip cooperates with HSP70 in protein folding by stabilizing the ADP-bound state of HSP70. Hip directly binds to the ATPase domain of HSP70 when it is converted to the ADP-bound state by proteins of the HSP40 family. By collaborating with other positive co-factors such as HSP40 and Hop, or competing with negative co-factors such as Bag1, Hip may facilitate the chaperone function of HSP70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and various regulators of proliferation or apoptosis.

Product Overview
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
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Western Blot
Figure 1: Western blot analysis using ST13 mouse mAb against A431 (1), HEK293 (2), Hela (3), HepG2 (4), Jurkat (5), K562 (6), L121O (7) and MCF-7 (8) cell lysate.
Figure 1: Western blot analysis using ST13 mouse mAb against A431 (1), HEK293 (2), Hela (3), HepG2 (4), Jurkat (5), K562 (6), L121O (7) and MCF-7 (8) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B) using ST13 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), colon cancer (B) using ST13 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded human Thyroid tissues using ST13 mouse mAb
Figure 3: Immunohistochemical analysis of paraffin-embedded human Thyroid tissues using ST13 mouse mAb
Immunofluorescence analysis
Figure 4: Immunofluorescence analysis of NIH/3T3 cells using ST13 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 4: Immunofluorescence analysis of NIH/3T3 cells using ST13 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
For Research Use Only. Not for use in diagnostic procedures.