SRC Primary Antibody
|Aliases||ASV; SRC1; c-SRC; p60-Src|
|Formulation||Ascitic fluid containing 0.03% sodium azide. |
|Immunogen||Purified recombinant fragment of human SRC expressed in E. Coli. |
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|IHC_P(Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
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Figure 1: Western blot analysis using SRC mAb against human SRC (AA: 1-189) recombinant protein. (Expected MW is 47.8 kDa)
Figure 2: Western blot analysis using SRC mouse mAb against MCF-7 (1), A431 (2), Hela (3), HEK293 (4), NIH/3T3 (5), PC-12 (6) and Cos7 (7) cell lysate.
Figure 3: Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using SRC mouse mAb with DAB staining.
Figure 4: Immunohistochemical analysis of paraffin-embedded esophageal tissues using SRC mouse mAb with DAB staining.
Figure 5: Flow cytometric analysis of MCF-7 cells using SRC mouse mAb (green) and negative control (red).
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
|References (references)||1. Clin Cancer Res. 2009 Nov 15;15(22):6852-61. |
2. Cell. 2009 Nov 13;139(4):693-706.