SNCA Primary Antibody

Item Information
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Description

Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

Product Overview
Entrez GenelD
6622
Aliases
PD1; NACP; PARK1; PARK4; MGC110988
Clone#
2B2D1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of SNCA expressed in E. Coli.

Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. J. Johnson, S. M. Hague, M. Hanson. Neurology, Aug 2004; 63: 554 - 556
2. Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie. Protein Pept Lett. 2006;13(4):385-90.
Product Image
Western Blot
Figure 1: Western blot analysis using SNCA mouse mAb against truncated SNCA recombinant protein.
Figure 1: Western blot analysis using SNCA mouse mAb against truncated SNCA recombinant protein.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human glioma tissue, showing membrane localization using SNCA mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human glioma tissue, showing membrane localization using SNCA mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.