SMAD6 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesMADH6; MADH7; HsT17432; SMAD6
ProductOrderS
Clone#5H3
Entrez GenelD4091
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human SMAD6 expressed in E. Coli.

MW53kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
238-496
Catalog#: 30097
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Images
Western Blot
Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hela (3) and Jurkat (4) cell lysate.
Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hela (3) and Jurkat (4) cell lysate.
Product Overview
Description

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.

References (references)
References (references)1. J Biol Chem. 2006 Feb 10;281(6):3569-76.
2. Nat Immunol. 2006 Oct;7(10):1057-65.
3. J Med Genet. 2009 May;46(5):331-7.