SMAD6 Primary Antibody
Item Information
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Size
Price
Description
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Product Overview
Entrez GenelD
4091
Aliases
MADH6; MADH7; HsT17432; SMAD6
Clone#
5H3
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human SMAD6 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. J Biol Chem. 2006 Feb 10;281(6):3569-76.
2. Nat Immunol. 2006 Oct;7(10):1057-65.
3. J Med Genet. 2009 May;46(5):331-7.
2. Nat Immunol. 2006 Oct;7(10):1057-65.
3. J Med Genet. 2009 May;46(5):331-7.
Product Image
Western Blot
Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hela (3) and Jurkat (4) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.