SLINGSHOT-1L Primary Antibody
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purified antibody from tissue culture in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Flow cytometric analysis of Hela cells using SLINGSHOT-1L mouse mAb (green) and negative control (red).
Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SLINGSHOT-1L mouse mAb with DAB staining.
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.