S100A6 Primary Antibody
Item Information
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Description
Calcyclin encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
Product Overview
Entrez GenelD
6277
Aliases
S100A6; 2A9; PRA; 5B10; CABP; CACY
Clone#
7D11
Species Reactivity
Human
Immunogen
Purified recombinant fragment of calcyclin expressed in E. Coli.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Bean C.et.al J Mol Biol. 2005 Jun 3;349(2):349-66.
2. HWang R.et.al J Biol Chem. 2004 May 14;279(20):21239-47.
2. HWang R.et.al J Biol Chem. 2004 May 14;279(20):21239-47.
Product Image
Western Blot
Figure 1: Western blot analysis using calcyclin mouse mAb against truncated calcyclin recombinant protein.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human brain glioma tissue showing nuclear localization using calcyclin mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.