RTN3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHAP; ASYIP; NSPL2; NSPLII; RTN3-A1
ProductOrderR
Clone#1E11
Entrez GenelD10313
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2a
ImmunogenPurified recombinant fragment of RTN3 expressed in E. Coli.
MW113kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
Sequence
N
Catalog#: 20371
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Images
Immunofluorescence analysis
Figure 1: Confocal Immunofluorescence analysis of Hela (A), A431 (B) and THP-1 (C) cells using RTN3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 1: Confocal Immunofluorescence analysis of Hela (A), A431 (B) and THP-1 (C) cells using RTN3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.

References (references)
References (references)1. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1198-205.
2. Brain Res Mol Brain Res. 2005 Aug 18;138(2):236-43.
3. FASEB J. 2003 Jul;17(10):1238-47.