RTN3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHAP; ASYIP; NSPL2; NSPLII; RTN3-A1
ProductOrderR
Clone#10A8
Entrez GenelD10313
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2a
ImmunogenPurified recombinant fragment of RTN3 expressed in E. Coli.
MW113kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
Sequence
N
Catalog#: 20357
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Images
Immunohistochemical analysis
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and breast cancer (right) using RTN3 mouse mAb with DAB staining.
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and breast cancer (right) using RTN3 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human Liver tissues using RTN3 mouse mAb
Figure 2: Immunohistochemical analysis of paraffin-embedded human Liver tissues using RTN3 mouse mAb
Product Overview
Description

RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.

References (references)
References (references)1. Biochem Biophys Res Commun. 2005 Sep 9;334(4):1198-205.
2. Brain Res Mol Brain Res. 2005 Aug 18;138(2):236-43.
3. FASEB J. 2003 Jul;17(10):1238-47.