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RBFOX2 Primary Antibody
|Aliases||RTA; fxh; FOX2; RBM9; Fox-2; HNRBP2; HRNBP2; dJ106I20.3|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human RBFOX2 (AA: 1-145) expressed in E. Coli.|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using RBFOX2 mAb against human RBFOX2 (AA: 1-145) recombinant protein. (Expected MW is 41.9 kDa)
Figure 3:Western blot analysis using RBFOX2 mAb against HEK293 (1) and RBFOX2 (AA: 1-145)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of Jurkat cells using RBFOX2 mouse mAb (green) and negative control (red).
Figure 5:Immunohistochemical analysis of paraffin-embedded brain tissues using RBFOX2 mouse mAb with DAB staining.
This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|References (references)||1.Mol Cell Biol. 2013 Jan;33(2):396-405.
2.Sci Rep. 2016 Aug 3;6:30896.