RASSF1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
Aliases123F2; RDA32; NORE2A; RASSF1A; REH3P21
ProductOrderR
Clone#4G9A3
Entrez GenelD11186
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human RASSF1 expressed in E. Coli.
MW39kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
N
Catalog#: 20441
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Images
Western Blot
Figure 1: Western blot analysis using RASSF1 mouse mAb against HepG2 (1) and Jurkat (2) cell lysate.
Figure 1: Western blot analysis using RASSF1 mouse mAb against HepG2 (1) and Jurkat (2) cell lysate.
Flow cytometric
Figure 2: Flow cytometric analysis of HepG2 cells using RASSF1 mouse mAb (green) and negative control (purple).
Figure 2: Flow cytometric analysis of HepG2 cells using RASSF1 mouse mAb (green) and negative control (purple).
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using RASSF1 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using RASSF1 mouse mAb with DAB staining.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
DescriptionThis gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.




References (references)
References (references)1.Cancer Res. 2012 May 1;72(9):2206-17.
2.Cancer Biomark. 2011-2012;10(1):13-26.