Rab8 Primary Antibody
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Description
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
Product Overview
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Image
Elisa

Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western Blot

Figure 2:Western blot analysis using Rab8 mAb against human Rab8 (AA: 68-207) recombinant protein. (Expected MW is 42 kDa)
Western Blot

Figure 3:Western blot analysis using Rab8 mAb against HEK293 (1) and Rab8 (AA: 68-207)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric

Figure 4:Flow cytometric analysis of HeLa cells using Rab8 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.