PTPRU Primary Antibody

Item Information
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Price
Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.

Product Overview
Entrez GenelD
10076
Aliases
FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; PTP-PI; PTP-RO; PTPPSI; hPTP-J; R-PTP-U; R-PTP-PSI
Clone#
1A6E5
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human PTPRU (AA: extra 579-749) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1.Int J Clin Exp Pathol. 2014 Aug 15;7(9):5750-61.2.Carcinogenesis. 2014 Aug;35(8):1901-10.
Product Image
Elisa
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using PTPRU mAb against human PTPRU (AA: extra 579-749) recombinant protein. (Expected MW is 45 kDa)
Figure 2:Western blot analysis using PTPRU mAb against human PTPRU (AA: extra 579-749) recombinant protein. (Expected MW is 45 kDa)
Western Blot
Figure 3:Western blot analysis using PTPRU mAb against HEK293 (1) and PTPRU (AA: extra 579-749)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using PTPRU mAb against HEK293 (1) and PTPRU (AA: extra 579-749)-hIgGFc transfected HEK293 (2) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.

Catalog#: 31472

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