PTPRD Primary Antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5.
![Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31467ea.jpg?v=1666703722)
![Figure 2:Western blot analysis using PTPRD mAb against human PTPRD (AA: extra 1077-1265) recombinant protein. (Expected MW is 47.4 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31467rwb.jpg?v=1666703722)
![Figure 3:Western blot analysis using PTPRD mAb against HEK293 (1) and PTPRD (AA: extra 1077-1265)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31467twb.jpg?v=1666703722)
![Figure 4:Flow cytometric analysis of HL-60 cells using PTPRD mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31467fcm.jpg?v=1666703722)