PTH1R Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPFE; PTHR; PTHR1; MGC138426; MGC138452; PTH1R
ProductOrderP
Clone#4D2
Entrez GenelD5745
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PTH1R expressed in E. Coli.
MW66kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
27-188
Catalog#: 30085
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Images
Western Blot
Figure 1: Western blot analysis using PTH1R mAb against PTH1R (AA: 27-188)-hIgGFc transfected HEK293 cell lysate.
Figure 1: Western blot analysis using PTH1R mAb against PTH1R (AA: 27-188)-hIgGFc transfected HEK293 cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human kidney tissues using PTH1R mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human kidney tissues using PTH1R mouse mAb with DAB staining.
Immunofluorescence analysis
Figure 3: Immunofluorescence analysis of SK-BR-3 cells using PTH1R mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 3: Immunofluorescence analysis of SK-BR-3 cells using PTH1R mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Product Overview
Description

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.

References (references)
References (references)1. Int J Cancer. 2007 Sep 1;121(5):943-54.
2. Mol Endocrinol. 2008 Jan;22(1):156-66.