Proteinase 3 Primary Antibody
Item Information
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Size
Price
Description
Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Product Overview
Entrez GenelD
5657
Aliases
PRTN3; ACPA; CANCA
Clone#
3B4
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Blood. 2007 Dec 1;110(12):4086-95.
2. Clin Exp Immunol. 2006 Jul;145(1):63-70.
2. Clin Exp Immunol. 2006 Jul;145(1):63-70.
Product Image
Western Blot
Figure 1: Western blot analysis using PRTN3 mouse mAb against PRTN3 (aa28-256)-hIgGFc transfected HEK293 cell lysate (1).
For Research Use Only. Not for use in diagnostic procedures.