Proteinase 3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPRTN3; ACPA; CANCA
ProductOrderP
Clone#3B4
Entrez GenelD5657
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human Proteinase 3 expressed in E. Coli.
MW28kDa
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Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
28-256
Catalog#: 20373
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Images
Western Blot
Figure 1: Western blot analysis using PRTN3 mouse mAb against PRTN3 (aa28-256)-hIgGFc transfected HEK293 cell lysate (1).
Figure 1: Western blot analysis using PRTN3 mouse mAb against PRTN3 (aa28-256)-hIgGFc transfected HEK293 cell lysate (1).
Product Overview
Description

Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

References (references)
References (references)1. Blood. 2007 Dec 1;110(12):4086-95.
2. Clin Exp Immunol. 2006 Jul;145(1):63-70.