PR Primary Antibody

Item Information

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Description

PR(progesterone receptor), with 933-amino acid protein (about 110kDa), a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone, PR is mediated by two functionally different isoforms of the progesterone receptor, the full length PR-B and the short form PR-A. The PR-A and PR-B proteins are 94 kDa and 114 kDa respectively. That are equimolar in the normal breast but dysregulated in advanced disease. PR is prognostic markers in breast cancers irrespective of the patient's progestational status Human progesterone.

Product Overview

Entrez GenelD

5241

Aliases

PR; NR3C3; PGR

Clone#

2F12B4

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of PR expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/10000

References

1. McGuire, W.L., et al. 1986. Cancer.Surv.5:527-536.
2. Helena CD, Curt WB, Paul V,et al. 2000. J.Clin. Pathol. 53:201-205.
3. Wen, D.X., et al. 1994.Mol.Cell.Biol.14:8356-8364.
4. GM Clark, CK Osborne, WL McGuire.1984.J. Clin. Oncol., 2:1102-1109.

Product Image

Western Blot

Figure 1: Western blot analysis using PR mouse mAb against PR recombinant protein (1).

Immunohistochemical analysis

Figure 2: Immunohistochemical analysis of paraffin-embedded human infiltrating ductal carcinoma tissue(left) and simple carcinoma of breast cancer tissue(right), showing nuclear localization using PR mouse mAb with DAB staining.

For Research Use Only. Not for use in diagnostic procedures.