PMAIP1 Primary Antibody
The protein encoded by this gene promotes activation of caspases and apoptosis, Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Purified antibody in PBS with 0.05% sodium azide
4?; -20? for long term storage
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using PMAIP1 mAb against human PMAIP1 (AA: 1-54) recombinant protein. (Expected MW is 32 kDa)
Figure 3:Western blot analysis using PMAIP1 mAb against HEK293 (1) and PMAIP1 (AA: 1-54)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using PMAIP1 mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.