PLAU
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
2.Molecules.2021 Mar 24;26(7):1816.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32276ea.jpg?v=1669029461)
![Figure 2:Western blot analysis using PLAU mAb against human PLAU (AA: 107-379) recombinant protein. (Expected MW is 34 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32276rwb.jpg?v=1669029461)
![Figure 3:Western blot analysis using PLAU mAb against HEK293-6e (1) and PLAU (AA: 107-379)-hIgGFc transfected HEK293-6e(2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32276twb.jpg?v=1669029461)
![Figure 6:Flow cytometric analysis of Hela cells using PLAU mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32276fcm.jpg?v=1669029461)
![Figure 7:Flow cytometric analysis of HepG2 cells using PLAU mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/32276-1fcm.jpg?v=1669029461)