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PIDD1 Primary Antibody
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human PIDD1 (AA: 776-910) expressed in E. Coli.|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using PIDD1 mAb against human PIDD1 (AA: 776-910) recombinant protein. (Expected MW is 40.8 kDa)
Figure 3:Western blot analysis using PIDD1 mAb against HEK293 (1) and PIDD1 (AA: 776-910)-hIgGFc transfected HEK293 (2) cell lysate.
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
|References (references)||1.Tumour Biol. 2016 Aug;37(8):10447-57.
2.Br J Cancer. 2007 May 7;96(9):1425-32.