PDX1 Primary Antibody
|Aliases||GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human PDX1 expressed in E. Coli. |
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
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Figure 1: Western blot analysis using PDX1 mAb against human PDX1 (AA: 39-283) recombinant protein. (Expected MW is 52 kDa)
Figure 2: Western blot analysis using PDX1 mAb against HEK293 (1) and PDX1 (AA: 39-283)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3: Flow cytometric analysis of Jurkat cells using PDX1 mouse mAb (green) and negative control (red).
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
|References (references)||Am J Clin Pathol. 2011 Feb;135(2):253-61. |
Pancreas. 2010 Aug;39(6):856-62.