PDX1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesGSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1
ProductOrderP
Clone#5A5
Entrez GenelD3651
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PDX1 expressed in E. Coli.
MW30.8kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
39-283
Catalog#: 30342
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Images
Western Blot
Figure 1: Western blot analysis using PDX1 mAb against human PDX1 (AA: 39-283) recombinant protein. (Expected MW is 52 kDa)
Figure 1: Western blot analysis using PDX1 mAb against human PDX1 (AA: 39-283) recombinant protein. (Expected MW is 52 kDa)
Western Blot
Figure 2: Western blot analysis using PDX1 mAb against HEK293 (1) and PDX1 (AA: 39-283)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using PDX1 mAb against HEK293 (1) and PDX1 (AA: 39-283)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 3: Flow cytometric analysis of Jurkat cells using PDX1 mouse mAb (green) and negative control (red).
Figure 3: Flow cytometric analysis of Jurkat cells using PDX1 mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

References (references)
References (references)J Biol Chem. 2009 Dec 25;284(52):36482-90.
Pancreatology. 2009;9(1-2):116-26.