PAX8 Primary Antibody

Item Information
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Description

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas.Tissue specificity: Expressed in the excretory system, thyroid gland and Wilms tumors.ABCAM: This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.

Product Overview
Entrez GenelD
7849
Aliases
PAX8
Clone#
2D4
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human PAX8 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Thyroid. 2009 Jan;19(1):61-8.
2. Cancer Genet Cytogenet. 2010 Jan 1;196(1):7-13.
3. Cancer Cytopathol. 2010 Oct 25;118(5):298-302.
Product Image
Western Blot
Figure 1: Western blot analysis using PAX8 mouse mAb against Hela (1)?HEK293 (2) and Raji (3) cell lysate.
Figure 1: Western blot analysis using PAX8 mouse mAb against Hela (1)?HEK293 (2) and Raji (3) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.