PAX5 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesBSAP
ProductOrderP
Clone#7D3
Entrez GenelD5079
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.
MW45kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
235-382
Catalog#: 30395
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Images
Western Blot
Figure 1: Western blot analysis using PAX5 mAb against human PAX5 recombinant protein. (Expected MW is 41.2 kDa)
Figure 1: Western blot analysis using PAX5 mAb against human PAX5 recombinant protein. (Expected MW is 41.2 kDa)
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using PAX5 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using PAX5 mouse mAb with DAB staining.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

References (references)
References (references)1.Cancer Res. 2011 Dec 15;71(24):7345-50. 2.Am J Clin Pathol. 2010 Jan;133(1):41-8.