PARP Primary Antibody
|Aliases||PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Synthetic peptide of human PARP, conjugated to KLH.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
|References (references)||1. Cytogenet Cell Genet. 1992;61(3):172-4. |
2. J Immunol. 1997 Dec 1;159(11):5246-52.
3. J Biol Chem. 2001 Dec 7;276(49):45588-97.