PARP Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
ProductOrderP
Clone#7A10
Entrez GenelD142
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenSynthetic peptide of human PARP, conjugated to KLH.
MW117kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
peptide:CGGNAWHSKNFTKYPKKFY
Catalog#: 30016
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Images
Western Blot
Figure 1: Western blot analysis using PARP mouse mAb against Jurkat (1), K562 (2), Hela (3), Raji (4),THP-1 (5) and SW620 (6) cell lysate.
Figure 1: Western blot analysis using PARP mouse mAb against Jurkat (1), K562 (2), Hela (3), Raji (4),THP-1 (5) and SW620 (6) cell lysate.
Flow cytometric
Figure 2: Flow cytometric analysis of Jurkat cells using anti-PARP mAb (green) and negative control (purple).
Figure 2: Flow cytometric analysis of Jurkat cells using anti-PARP mAb (green) and negative control (purple).
Product Overview
Description

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

References (references)
References (references)1. Cytogenet Cell Genet. 1992;61(3):172-4.
2. J Immunol. 1997 Dec 1;159(11):5246-52.
3. J Biol Chem. 2001 Dec 7;276(49):45588-97.