PARL Primary Antibody
Item Information
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Size
Price
Description
PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Product Overview
Entrez GenelD
55486
Aliases
PSARL; PSARL1; RHBDS1
Clone#
8C4B2
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human
Immunogen
Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. J Alzheimers Dis. 2001 Apr;3(2):181-190.
2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
3. Nature. 2003 May 29;423(6939):537-41.
2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
3. Nature. 2003 May 29;423(6939):537-41.
Product Image
Western Blot
Figure 1: Western blot analysis using PARL mouse mAb against truncated Trx-PARL recombinant protein (1) and truncated MBP-PARL(aa112-167) recombinant protein (2).
For Research Use Only. Not for use in diagnostic procedures.