Oct4 Primary Antibody
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
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![Figure 1: Western blot analysis using Oct4 mouse mAb against NTERA-2 (1) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30119lwb.jpg?v=1666699128)
![Figure 2: Immunofluorescence analysis of NTERA-2 cells using Oct4 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30119icc.jpg?v=1666699128)
![Figure 3: Flow cytometric analysis of Jurkat cells using Oct4 mouse mAb (green) and negative control (purple).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30119fcm.jpg?v=1666699128)