NTRK3 Primary Antibody
Item Information
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Size
Price
Description
NTRK3 (neurotrophic tyrosine kinase, receptor, type 3), it is a member of the neurotrophic tyrosine receptor kinase (NTRK) family and plays an important role in the development and maintenance of neural tissues. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Product Overview
Entrez GenelD
4916
Aliases
TRKC; gp145(trkC)
Clone#
7H6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. BMC Cancer. 2007 Oct 31;7:202.
2. J Pathol. 2002 Aug;197(5):661-7.
2. J Pathol. 2002 Aug;197(5):661-7.
Product Image
Western Blot
Figure 1: Western blot analysis using NTRK3 mouse mAb against extracellular domain of human NTRK3 (aa32-429).
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human lymph node using NTRK3 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.