Notch3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesIMF2; CASIL; CADASIL
ProductOrderN
Clone#3E2D9
Entrez GenelD4854
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG2a
ImmunogenPurified recombinant fragment of human Notch3 (AA: 47-156) expressed in E. Coli.
MW243.6kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
extra(47-156)
Catalog#: 30904
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Images
Elisa
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western Blot
Figure 2:Western blot analysis using Notch3 mAb against human Notch3 (AA: 47-156) recombinant protein. (Expected MW is 37.3 kDa)
Figure 2:Western blot analysis using Notch3 mAb against human Notch3 (AA: 47-156) recombinant protein. (Expected MW is 37.3 kDa)
Western Blot
Figure 3:Western blot analysis using Notch3 mAb against HEK293 (1) and Notch3 (AA: 47-156)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3:Western blot analysis using Notch3 mAb against HEK293 (1) and Notch3 (AA: 47-156)-hIgGFc transfected HEK293 (2) cell lysate.
Product Overview
DescriptionThis gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
References (references)
References (references)1.Cancer Res. 2014 Jun 15;74(12):3282-93.
2.Int J Cancer. 2013 Dec 1;133(11):2577-86.