NFKBIB Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesIKBB; TRIP9; NFKBIB
ProductOrderN
Clone#7B4
Entrez GenelD4793
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human NFKBIB expressed in E. Coli.
MW45kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
124-356
Catalog#: 30082
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Images
Western Blot
Figure 1: Western blot analysis using NFKBIB mouse mAb against Jurkat (1) cell lysate.
Figure 1: Western blot analysis using NFKBIB mouse mAb against Jurkat (1) cell lysate.
Product Overview
Description

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined.

References (references)
References (references)1. Mol Cell Biol. 2004 Apr;24(7):3048-56.
2. J Biol Chem. 2004 Oct 15;279(42):44030-8.
3. J Bone Miner Res. 2009 Dec;24(12):2039-49.