MSI2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesMSI2H; MGC3245; FLJ36569; MSI2
ProductOrderM
Clone#2C11
Entrez GenelD124540
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human MSI2 expressed in E. Coli.
MW35kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
1-190
Catalog#: 30178
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Images
Western Blot
Figure 1: Western blot analysis using MSI2 mouse mAb against NTERA-2 (1), SW620 (2) and T47D (3) cell lysate.
Figure 1: Western blot analysis using MSI2 mouse mAb against NTERA-2 (1), SW620 (2) and T47D (3) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and cerebellum tissues (right) using MSI2 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and cerebellum tissues (right) using MSI2 mouse mAb with DAB staining.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous; detected at low levels.

References (references)
References (references)1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Haematologica. 2008 Dec;93(12):1903-7.