MSI2 Primary Antibody

Item Information

Catalog #

Size

Price

Description

Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous; detected at low levels.

Product Overview

Entrez GenelD

124540

Aliases

MSI2H; MGC3245; FLJ36569; MSI2

Clone#

2C11

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of human MSI2 expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

4°C; -20°C for long term storage

Product Applications

WB (Western Blot)

1/500 - 1/2000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/10000

References

1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Haematologica. 2008 Dec;93(12):1903-7.

Product Image

Western Blot

Figure 1: Western blot analysis using MSI2 mouse mAb against NTERA-2 (1), SW620 (2) and T47D (3) cell lysate.

Immunohistochemical analysis

Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and cerebellum tissues (right) using MSI2 mouse mAb with DAB staining.

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