MSH6 Primary Antibody

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Description

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Product Overview
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4?; -20? for long term storage
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Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using TUBB3 mouse mAb against NIH/3T3 (1), Hela (2), and A549 (3) cell lysate.
Figure 2:Western blot analysis using TUBB3 mouse mAb against NIH/3T3 (1), Hela (2), and A549 (3) cell lysate.
Flow Cytometric
Figure 3:Flow cytometric analysis of Hela cells using TUBB3 mouse mAb (green) and negative control (red).
Figure 3:Flow cytometric analysis of Hela cells using TUBB3 mouse mAb (green) and negative control (red).
Immunohistochemical Analysis
Figure 4:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using TUBB3 mouse mAb with DAB staining.
Figure 4:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using TUBB3 mouse mAb with DAB staining.
Immunohistochemical Analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded cerebellum tissues using TUBB3 mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded cerebellum tissues using TUBB3 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.