MMP2 Primary Antibody
Item Information
Catalog #
Size
Price
Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Product Overview
Entrez GenelD
4313
Aliases
CLG4; MONA; CLG4A; TBE-1; MMP-II
Clone#
4D1E2
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human MMP2 (AA: 242-396) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1.Br J Cancer. 2012 Apr 24;106(9):1495-8.
2.Iran J Immunol. 2011 Jun;8(2):120-6.
2.Iran J Immunol. 2011 Jun;8(2):120-6.
Product Image
Western Blot
Figure 1: Western blot analysis using MMP2 mAb against human MMP2 recombinant protein. (Expected MW is 42.8 kDa)
Western Blot
Figure 2: Western blot analysis using MMP2 mouse mAb against A431 (1) cell lysate.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.