MDM2 Primary Antibody

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Description

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Product Overview
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
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ELISA
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)
WESTERN BLOT
Figure 2: Western blot analysis using MDM2 mAb against human MDM2 (AA: 26-169) recombinant protein. (Expected MW is *** kDa)
Figure 2: Western blot analysis using MDM2 mAb against human MDM2 (AA: 26-169) recombinant protein. (Expected MW is *** kDa)
WESTERN BLOT
Figure 3: Western blot analysis using MDM2 mAb against HEK293 (1) and MDM2 (AA: 26-169)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3: Western blot analysis using MDM2 mAb against HEK293 (1) and MDM2 (AA: 26-169)-hIgGFc transfected HEK293 (2) cell lysate.
FLOW CYTOMETRY
Figure 4: Flow cytometric analysis of Hela cells using MDM2 mouse mAb (green) and negative control (red).
Figure 4: Flow cytometric analysis of Hela cells using MDM2 mouse mAb (green) and negative control (red).
IMMUNOHISTOCHEMISTRY
Figure 5: Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using MDM2 mouse mAb with DAB staining.
Figure 5: Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using MDM2 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.