MDM2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesDMX; hdm2; ACTFS
ProductOrderM
Clone#6B12D2
Entrez GenelD4193
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenSynthesized peptide of human MDM2 (AA: cSRPSTSSRRRAISE).
MW55.2kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
Sequence
cSRPSTSSRRRAISE
Catalog#: 30750
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Images
Flow cytometric
Figure 1: Flow cytometric analysis of Hela cells using MDM2 mouse mAb (green) and negative control (red).
Figure 1: Flow cytometric analysis of Hela cells using MDM2 mouse mAb (green) and negative control (red).
Flow cytometric
Figure 2: Flow cytometric analysis of Jurkat cells using MDM2 mouse mAb (green) and negative control (red).
Figure 2: Flow cytometric analysis of Jurkat cells using MDM2 mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

References (references)
References (references)Asian Pac J Cancer Prev. 2013;14(3):1925-9.
Biomaterials. 2013 Apr;34(11):2738-47.