MDM2 Primary Antibody
|Aliases||DMX; hdm2; ACTFS|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Synthesized peptide of human MDM2 (AA: ASEQETLVRPKPLLc).|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|FCM (Flow Cytometry)||1/200 - 1/400|
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
|References (references)||Asian Pac J Cancer Prev. 2013;14(3):1925-9. |
Biomaterials. 2013 Apr;34(11):2738-47.