MCM3AP Primary Antibody

Item Information
Catalog # Size/Concentration Price
31735 100ug $341.00
Specification
AliasesGANP; SAC3; MAP80; PNRIID
Clone#5B2C4
Entrez GeneID8888
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenMouse IgG1
MW62.8kDa
Application
ELISA1/10000
IHC_P (Immunohistochemistry) Purified recombinant fragment of human PINK1 (AA: 112-273) expressed in E. Coli.
Sequence
(AA: 293-442) expressed in E. Coli.
Catalog
31735
$341.00
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Images

Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Cell Culture Products

Figure 2: Western blot analysis using MCM3AP mAb against human MCM3AP (AA: 293-442) recombinant protein. (Expected MW is 42.5 kDa)

Cell Culture Products

Figure 3: Western blot analysis using MCM3AP mAb against HEK293 (1) and MCM3AP (AA: 293-442)-hIgGFc transfected HEK293 (2) cell lysate.

Cell Culture Products
Tissue Array Results
Position Tissues Name Result Localization
Nucleus Cytoplasm Membrane
E9/10 Endometrial Cancer
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Product Overview
Description

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.

References (references)
References (references) 1.Biomed Pharmacother. 2018 Oct;106:333-341.
2.Cancer Res. 2016 Aug 15;76(16):4708-19.

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