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MCM3AP Primary Antibody
|Aliases||GANP; SAC3; MAP80; PNRIID|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|IHC_P (Immunohistochemistry)||Purified recombinant fragment of human PINK1 (AA: 112-273) expressed in E. Coli.|
|(AA: 293-442) expressed in E. Coli.|
Figure 1: Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2: Western blot analysis using MCM3AP mAb against human MCM3AP (AA: 293-442) recombinant protein. (Expected MW is 42.5 kDa)
Figure 3: Western blot analysis using MCM3AP mAb against HEK293 (1) and MCM3AP (AA: 293-442)-hIgGFc transfected HEK293 (2) cell lysate.
|Tissue Array Results|
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The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.
|References (references)||1.Biomed Pharmacother. 2018 Oct;106:333-341.
2.Cancer Res. 2016 Aug 15;76(16):4708-19.