MATK Primary Antibody
Item Information
Catalog #
Size
Price
Description
MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
Product Overview
Entrez GenelD
4145
Aliases
CHK; CTK
Clone#
9D7
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human MATK expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1. Int J Oncol. 2002 Jul;21(1):197-205.
2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
3. Nat Genet. 2004 Jan;36(1):40-5.
2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903.
3. Nat Genet. 2004 Jan;36(1):40-5.
Product Image
Western Blot
Figure 1: Western blot analysis using MATK mouse mAb against K562 cell lysate (1).
Flow cytometric
Figure 2: Flow cytometric analysis of K562 cells using MATK mouse mAb (green) and negative control (purple).
For Research Use Only. Not for use in diagnostic procedures.