MAPK7 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesBMK1; ERK4; ERK5; PRKM7
ProductOrderM
Clone#8H1D5
Entrez GenelD5598
FormulationPurified antibody in PBS with 0.05% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human MAPK7 (AA: 411-556) expressed in E. Coli.
MW88.4kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
411-556
Catalog#: 30654
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Images
Western Blot
Figure 1: Western blot analysis using MAPK7 mAb against human MAPK7 (AA: 411-556) recombinant protein. (Expected MW is 41.8 kDa)
Figure 1: Western blot analysis using MAPK7 mAb against human MAPK7 (AA: 411-556) recombinant protein. (Expected MW is 41.8 kDa)
Western Blot
Figure 2: Western blot analysis using MAPK7 mAb against HEK293 (1) and MAPK7 (AA: 411-556)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using MAPK7 mAb against HEK293 (1) and MAPK7 (AA: 411-556)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using MAPK7 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using MAPK7 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 4: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using MAPK7 mouse mAb with DAB staining.
Figure 4: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using MAPK7 mouse mAb with DAB staining.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

References (references)
References (references)1. Br J Cancer. 2011 Feb 15;104(4):664-72.
2. PLoS One. 2009;4(5):e5565.