MAP4K4 Primary Antibody
Item Information
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Description
MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Overview
Entrez GenelD
9448
Aliases
HGK; NIK
Clone#
3C7B5
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Mol Cell Biol. 2000 Mar;20(5):1537-45.
2. Curr Biol. 2002 Apr 16;12(8):622-31.
3. J Biol Chem. 2007 Mar 16;282(11):7783-9.
2. Curr Biol. 2002 Apr 16;12(8):622-31.
3. J Biol Chem. 2007 Mar 16;282(11):7783-9.
Product Image
Western Blot
Figure 1: Western blot analysis using MAP4K4 mouse mAb against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4(aa194-436)-hIgGFc transfected CH0-K1 cell lysate(3).
For Research Use Only. Not for use in diagnostic procedures.