MAP3K2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesMEKK2; MEKK2B
ProductOrderM
Clone#4B4
Entrez GenelD10746
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human MAP3K2 expressed in E. Coli.
MW70kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
148-359
Catalog#: 30273
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Images
Western Blot
Figure 1: Western blot analysis using MAP3K2 mAb against human MAP3K2 (AA: 148-359) recombinant protein. (Expected MW is 49.2 kDa)
Figure 1: Western blot analysis using MAP3K2 mAb against human MAP3K2 (AA: 148-359) recombinant protein. (Expected MW is 49.2 kDa)
Western Blot
Figure 2: Western blot analysis using MAP3K2 mAb against HEK293 (1) and MAP3K2(AA: 148-359)--hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using MAP3K2 mAb against HEK293 (1) and MAP3K2(AA: 148-359)--hIgGFc transfected HEK293 (2) cell lysate.
Immunofluorescence analysis
Figure 3: Immunofluorescence analysis of 3T3-L1 cells using MAP3K2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Figure 3: Immunofluorescence analysis of 3T3-L1 cells using MAP3K2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

References (references)
References (references)1. Clin Cancer Res. 2009 Sep 1;15(17):5541-51. 
2. J Biol Chem. 2009 May 15;284(20):13533-41.