MAP2K6 Primary Antibody

Item Information
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Price
Description

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.

Product Overview
Entrez GenelD
5608
Aliases
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6
Clone#
3H12B9
Host / Isotype
Mouse / IgG1
Species Reactivity
Human, Mouse
Immunogen
Purified recombinant fragment of human MAP2K6 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. J Mol Med. 2008 Apr;86(4):485-90.
2. Blood. 2007 Jan 1;109(1):185-93.
Product Image
Western Blot
Figure 1: Western blot analysis using MAP2K6 mouse mAb against HepG2 (1), MCF-7 (2) and NIH/3T3 (3) cell lysate.
Figure 1: Western blot analysis using MAP2K6 mouse mAb against HepG2 (1), MCF-7 (2) and NIH/3T3 (3) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and kidney cancer (right) using MAP2K6 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded ovarian cancer (left) and kidney cancer (right) using MAP2K6 mouse mAb with DAB staining.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
For Research Use Only. Not for use in diagnostic procedures.